Mac & Cheese Meatloaf Casserole

Creamy mac & cheese meets juicy meatloaf in one unforgettable casserole.

🍽️ Mac & Cheese Meatloaf Casserole

A viral comfort-food casserole that layers creamy mac & cheese with juicy, flavorful meatloaf — baked together into the ultimate family dinner. Cheesy, hearty, and insanely delicious! 😍🔥

Recipe Overview

  • 🍴 Servings: 6–8

  • ⏱️ Prep Time: 10 minutes

  • 🔥 Cook Time: 35–40 minutes

  • 🍲 Total Time: 45–50 minutes

  • Difficulty: Easy

  • 📌 Category: Casserole, Dinner, Comfort Food

🧂 Ingredients

For the Meatloaf Layer

  • 1 ½ lbs ground beef

  • 1 egg

  • ½ cup breadcrumbs

  • ½ cup milk

  • 1 small onion, diced

  • 1 tsp garlic powder

  • 1 tsp onion powder

  • 1 tbsp Worcestershire sauce

  • 1 tsp salt

  • ½ tsp black pepper

  • ½ cup ketchup (plus extra for topping)

For the Mac & Cheese Layer

  • 3 cups cooked macaroni (or shells)

  • 2 cups shredded cheddar

  • 1 cup milk

  • 2 tbsp butter

  • 2 tbsp flour

  • ½ tsp mustard powder (optional — adds flavor!)

  • ½ tsp paprika

  • Pinch of salt & pepper

🔪 Tools You’ll Need

(Add your Amazon affiliate links here)

🥄 Mixing bowls

🥘 9×13 baking dish

🧀 Cheese grater

🍳 Skillet or saucepan

🍗 Meat thermometer

🎛️ Measuring cups & spoons

🥣 Instructions

Step 1 — Preheat

Preheat oven to 375°F and grease a 9×13 casserole dish.

Step 2 — Make the Meatloaf Base

In a large bowl, combine:

  • ground beef

  • egg

  • breadcrumbs

  • milk

  • onion

  • garlic powder

  • onion powder

  • Worcestershire

  • salt & pepper

Mix gently — don’t overwork it.

Press the mixture evenly into the bottom of your casserole dish.

Spread a thin layer of ketchup on top.

Bake 15 minutes to partially cook.

Step 3 — Make the Homemade Mac & Cheese

While the meatloaf bakes:

  1. Melt butter in a pot

  2. Whisk in flour to form a roux

  3. Add milk and whisk until creamy

  4. Stir in cheese, paprika, mustard powder, salt & pepper

  5. Mix in cooked macaroni

(OR you can use boxed mac & cheese to save time — Pinterest moms love this shortcut!)

Step 4 — Layer the Casserole

Remove meatloaf from oven.

Spread the mac & cheese evenly on top.

Sprinkle extra cheddar over the top.

Step 5 — Bake

Bake uncovered for 20–25 minutes, until:

✔ cheese is melted & golden
✔ edges are bubbly
✔ internal temp is 160°F (meatloaf fully cooked)

Step 6 — Serve

Let rest 5–10 minutes before slicing like a layered casserole.

Comfort food HEAVEN. 😍🔥

💡 Tips

  • Add bacon for extra flavor

  • Use pepper jack for spicy mac

  • Swap ground beef for turkey

  • Drizzle BBQ sauce instead of ketchup

  • Add onion rings on top for crunch

❄️ Storage

  • Refrigerate: 3–4 days

  • Freeze: Up to 2 months

  • Reheat: 350°F for 15 minutes

Gallery

Snapshots of our cheesy, meaty casserole magic.

FAQs

What is this?

It’s a cozy casserole layering mac & cheese with juicy meatloaf.

How long to bake?

Bake at 350°F for about 45 minutes until bubbly and golden on top.

Can I make it ahead?

Yes! Assemble it the day before, cover tightly, and bake fresh when ready.

Is it kid-friendly?

Absolutely, kids love the cheesy, meaty layers and comforting flavors.

Can I freeze it?

Yes, freeze before baking and thaw overnight in the fridge.

What sides go well with it?

Try a crisp green salad or steamed veggies to balance the rich casserole.

This mac & cheese meatloaf casserole is pure comfort in every bite—my family asks for it every week!

Amy K.

A warm, golden-baked mac & cheese meatloaf casserole fresh out of the oven, with gooey cheese stretching as a slice is lifted.
A warm, golden-baked mac & cheese meatloaf casserole fresh out of the oven, with gooey cheese stretching as a slice is lifted.

★★★★★