Mac & Cheese Meatloaf Casserole

Tools Needed
Ingredients

For the Meatloaf Layer

  • 1 ½ lbs ground beef

  • 1 egg

  • ½ cup breadcrumbs

  • ½ cup milk

  • 1 small onion, diced

  • 1 tsp garlic powder

  • 1 tsp onion powder

  • 1 tbsp Worcestershire sauce

  • 1 tsp salt

  • ½ tsp black pepper

  • ½ cup ketchup (plus extra for topping)

Instructions

Step 1 — Preheat
Preheat oven to 375°F and grease a 9×13 casserole dish.

Step 2 — Make the Meatloaf Base
In a large bowl, combine:

  • ground beef

  • egg

  • breadcrumbs

  • milk

  • onion

  • garlic powder

  • onion powder

  • Worcestershire

  • salt & pepper

Mix gently — don’t overwork it.

Press the mixture evenly into the bottom of your casserole dish.

Spread a thin layer of ketchup on top.

Bake 15 minutes to partially cook.

Step 3 — Make the Homemade Mac & Cheese
While the meatloaf bakes:

  1. Melt butter in a pot

  2. Whisk in flour to form a roux

  3. Add milk and whisk until creamy

  4. Stir in cheese, paprika, mustard powder, salt & pepper

  5. Mix in cooked macaroni

(OR you can use boxed mac & cheese to save time — Pinterest moms love this shortcut!)

Step 4 — Layer the Casserole
Remove meatloaf from oven.

Spread the mac & cheese evenly on top.

Sprinkle extra cheddar over the top.

Step 5 — Bake

Bake uncovered for 20–25 minutes, until:

✔ cheese is melted & golden
✔ edges are bubbly
✔ internal temp is 160°F (meatloaf fully cooked)

Step 6 — Serve

Let rest 5–10 minutes before slicing like a layered casserole.

For the Mac & Cheese Layer

  • 3 cups cooked macaroni (or shells)

  • 2 cups shredded cheddar

  • 1 cup milk

  • 2 tbsp butter

  • 2 tbsp flour

  • ½ tsp mustard powder (optional — adds flavor!)

  • ½ tsp paprika

  • Pinch of salt & pepper

Frequently Asked Questions

What is this?

It’s a cozy casserole layering mac & cheese with juicy meatloaf.

How long to bake?

Bake at 350°F for about 45 minutes until bubbly and golden on top.

Can I make it ahead?

Yes! Assemble it the day before, cover tightly, and bake fresh when ready.

Is it kid-friendly?

Absolutely, kids love the cheesy, meaty layers and comforting flavors.

Can I freeze it?

Yes, freeze before baking and thaw overnight in the fridge.

What sides go well with it?

Try a crisp green salad or steamed veggies to balance the rich casserole.